Open AccessCardiac telocytes exist in the adult Xenopus tropicalis heart
Author(s) -
Lv Luocheng,
Liao Zhaofu,
Luo Jiali,
Chen Hongyi,
Guo Hongyan,
Yang Jifeng,
Huang Ruijin,
Pu Qin,
Zhao Hui,
Yuan Ziqiang,
Feng Shanshan,
Qi Xufeng,
Cai Dongqing
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14947
Subject(s) - xenopus , regeneration (biology) , biology , ultrastructure , immunohistochemistry , anatomy , pathology , microbiology and biotechnology , medicine , genetics , gene
Abstract Recent research has revealed that cardiac telocytes (CTs) play an important role in cardiac physiopathology and the regeneration of injured myocardium. Recently, we reported that the adult Xenopus tropicalis heart can regenerate perfectly in a nearly scar‐free manner after injury via apical resection. However, whether telocytes exist in the X tropicalis heart and are affected in the regeneration of injured X tropicalis myocardium is still unknown. The present ultrastructural and immunofluorescent double staining results clearly showed that CTs exist in the X tropicalis myocardium. CTs in the X tropicalis myocardium were mainly twined around the surface of cardiomyocyte trabeculae and linked via nanocontacts between the ends of the telopodes, forming a three‐dimensional network. CTs might play a role in the regeneration of injured myocardium.