Open AccessChicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d ‐galactosamine induced acute liver injury
Author(s) -
Li Zheng,
Feng Haihua,
Han Lu,
Ding Lu,
Shen Bingyu,
Tian Ye,
Zhao Lilei,
Jin Meiyu,
Wang Qi,
Qin Haiyan,
Cheng Jiaqi,
Liu Guowen
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14935
Subject(s) - ampk , autophagy , liver injury , lipopolysaccharide , galactosamine , inflammation , oxidative stress , chemistry , protein kinase a , kinase , pharmacology , biochemistry , medicine , apoptosis , glucosamine
Chicoric acid is polyphenol of natural plant and has a variety of bioactivity. Caused by various kinds of stimulating factors, acute liver injury has high fatality rate. The effect of chicoric acid in acute liver injury induced by Lipopolysaccharide (LPS) and d ‐galactosamine ( d ‐GalN) was investigated in this study. The results showed that CA decreased the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and reduced the mortality induced by LPS/ d ‐GalN. CA can restrain mitogen‐activated protein kinases (MAPKs) and nuclear factor‐kappa B (NF‐κB) to alleviate inflammation. Meanwhile, the results indicated CA can active nuclear factor‐erythroid 2‐related factor 2 (Nrf2) pathway with increasing the level of AMP‐activated protein kinase (AMPK). And with the treatment of CA, protein levels of autophagy genes were obvious improved. The results of experiments indicate that CA has protective effect in liver injury, and the activation of AMPK and autophagy may make sense.