Open Accessm 6 A facilitates YTHDF‐independent phase separation
Author(s) -
Liu SiYu,
Feng Yi,
Wu Jun-Jie,
Zou Ming-Li,
Sun Zi-Li,
Li Xia,
Yuan FengLai
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14847
Subject(s) - rna , messenger rna , transcriptome , biology , phase (matter) , microbiology and biotechnology , computational biology , chemistry , gene expression , genetics , gene , organic chemistry
N6‐methyladenosine (m 6 A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature , Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition of the phase‐separated transcriptome on the basis of number and distribution, and provide strong evidence that m6A plays a role in regulating phase separation in cells.