Open AccessMicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway
Author(s) -
He Jianya,
Ye Wen,
Kou Ni,
Chen Kang,
Cui Bai,
Zhang Xiaohong,
Hu Shuhai,
Liu Tingjiao,
Kang Lan,
Li Xiaojie
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14794
Subject(s) - microrna , protein kinase b , cancer research , basal cell , cell , biology , cell migration , pi3k/akt/mtor pathway , medicine , signal transduction , pathology , microbiology and biotechnology , gene , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) is aggressive accompanied with poor prognosis. We previously isolated the most invasive cells resembling the invasive tumour front by microfluidic technology and explored their differentially expressed microRNAs (miRNAs) in our previous work. Here, we verified the miR‐29b‐3p as a guarder that suppressed migration and invasion of OSCC cells and was down‐regulated in the most invasive cells. Besides that, the invasion suppression role of miR‐29b‐3p was achieved through the IL32/AKT pathway. Thus, miR‐29b‐3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC.