Open AccessTNIP1‐mediated TNF‐α/NF‐κB signalling cascade sustains glioma cell proliferation
Author(s) -
Lei Qingchun,
Gu Huan,
Li Lei,
Wu Tingting,
Xie Wentao,
Li Meizhang,
Zhao Ninghui
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14760
Subject(s) - glioma , nf κb , tumor necrosis factor alpha , cancer research , immune system , cell growth , biology , cell , cytokine , medicine , microbiology and biotechnology , signal transduction , immunology , genetics
As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF‐α/NF‐κB axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF‐α/NF‐κB in glioma tissue. Glioma cell proliferation was activated with TNF‐α treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for IκB degradation and NF‐κB nucleus translocation, and consequently erased TNFα‐induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1‐mediated TNF‐α/NF‐κB axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.