Open AccessCrosstalk between cancer‐associated fibroblasts and immune cells in cancer
Author(s) -
An Yuanyuan,
Liu Fengtian,
Chen Ying,
Yang Qing
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14745
Subject(s) - crosstalk , immune system , cancer associated fibroblasts , tumor microenvironment , cancer cell , cancer research , carcinogenesis , biology , metastasis , immunology , cancer , physics , genetics , optics
Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.