Open AccessLong non‐coding RNA expressed in macrophage co‐varies with the inflammatory phenotype during macrophage development and polarization
Author(s) -
Xie Yixin,
Wang Min,
Tian Jingjing,
Li Xianping,
Yang Min,
Zhang Kan,
Tan Shan,
Luo Lingli,
Luo Can,
Peng Longkai,
Tang Aiguo
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14557
Subject(s) - macrophage polarization , macrophage , biology , immune system , phenotype , long non coding rna , computational biology , microarray , rna , microarray analysis techniques , transcriptome , gene , inflammation , function (biology) , gene expression , bioinformatics , microbiology and biotechnology , immunology , genetics , in vitro
Advances in microarray, RNA‐seq and omics techniques, thousands of long non‐coding RNAs (lncRNAs) with unknown functions have been discovered. LncRNAs have presented a diverse perspective on gene regulation in diverse biological processes, especially in human immune response. Macrophages participate in the whole phase of immune inflammatory response. They are able to shape their phenotype and arouse extensive functional activation after receiving physiological and pathological stimuli. Emerging studies indicated that lncRNAs participated in the gene regulatory network during complex biological processes of macrophage, including macrophage‐induced inflammatory responses. Here, we reviewed the existing knowledges of lncRNAs in the processes of macrophage development and polarization, and their roles in several different inflammatory diseases. Specifically, we focused on how lncRNAs function in macrophage, which might help to discover some potential therapeutic targets and diagnostic biomarkers.