Open AccessLong non‐coding RNAs in the spinal cord injury: Novel spotlight
Author(s) -
Li Zheng,
Ho Idy H. T.,
Li Xingye,
Xu Derong,
Wu William K. K.,
Chan Matthew T. V.,
Li Shugang,
Liu Xiaodong
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14422
Subject(s) - spinal cord injury , neuroscience , microrna , transcriptome , spinal cord , central nervous system , long non coding rna , biology , bioinformatics , nervous system , medicine , rna , gene , gene expression , genetics
Spinal cord injury (SCI) may lead to persistent locomotor dysfunction and somatosensory disorders, which adversely affect the quality of life of patients and cause a significant economic burden to the society. The efficacies of current therapeutic interventions are still far from satisfaction as the secondary damages resulting from the complex and progressive molecular alterations after SCI are not properly addressed. Recent studies revealed that long non‐coding RNAs (lncRNAs) are abundant in the brain and might play critical roles in several nervous system disorders. At the cellular level, lncRNAs have been shown to regulate the expression of protein‐coding RNAs and hence participate in neuronal death, demyelination and glia activation. Notably, SCI is characterized by these biological processes, suggesting that lncRNAs could be novel modulators in the pathogenesis of SCI. This review describes recent progresses in the lncRNA transcriptome analyses and their molecular functions in regulating SCI progression.