Open AccessStaphylococcus epidermidis role in the skin microenvironment
Author(s) -
Leonel Caroline,
Sena Isadora F. G.,
Silva Walison N.,
Prazeres Pedro H. D. M.,
Fernandes Gabriel R.,
Mancha Agresti Pamela,
Martins Drumond Mariana,
Mintz Akiva,
Azevedo Vasco A. C.,
Birbrair Alexander
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14415
Subject(s) - staphylococcus epidermidis , wound healing , immune system , skin repair , immunology , medicine , biology , staphylococcus aureus , bacteria , genetics
Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims to restore the cutaneous’ barrier role. Deciphering the underlying mechanistic details that contribute to wound healing will create novel therapeutic strategies for skin repair. Recently, by using state‐of‐the‐art technologies, it was revealed that the cutaneous microbiota interact with skin immune cells. Strikingly, commensal Staphylococcus epidermidis ‐induced CD8+ T cells induce re‐epithelization of the skin after injury, accelerating wound closure. From a drug development perspective, the microbiota may provide new therapeutic candidate molecules to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of the microbiota in the skin microenvironment.