Open AccessThe exploration of mechanisms of comorbidity between migraine and depression
Author(s) -
Zhang Qing,
Shao Anwen,
Jiang Zhengyan,
Tsai Huitzong,
Liu Weibo
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14390
Subject(s) - comorbidity , migraine , biopsychosocial model , depression (economics) , psychiatry , mechanism (biology) , clinical psychology , medicine , psychology , philosophy , epistemology , economics , macroeconomics
Migraine comorbid with depression is common and is often encountered in clinical practice. The comorbidity may lead to more serious conditions with other symptoms and a longer duration of treatment and it may impose heavy economic and social burdens, directly or indirectly, on patients and their families. Numerous studies have been published on the association of migraine with depression. Numerous literature have showed that the comorbidity may have a common complicated pathogenic mechanism involving biopsychosocial characteristics, including abnormal brain development and shared genetic basis, as well as neurotransmitters, sex hormones and stress. In addition, some studies have identified the multiple, bidirectional relationship between migraine and depressive disorder. We searched the literature for the possible common mechanisms between migraine and depression and classified the research results.