Open AccessSave your gut save your age: The role of the microbiome in stem cell ageing
Author(s) -
Tan Yi,
Wei Zongke,
Chen Jiaoliu,
An Junli,
Li Manling,
Zhou Liuyun,
Men Yanhua,
Zhao Shan
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14373
Subject(s) - stem cell , ageing , microbiome , biology , epigenetics , immune system , dysbiosis , gut flora , homeostasis , microbiology and biotechnology , immunology , bioinformatics , genetics , gene
Abstract The tremendous importance of microbiota in microbial homoeostasis, alterations in metabolism and both innate and adaptive immune systems has been well established. A growing body of evidence support that dysbiosis or compositional changes in gut microbiota is linked to the ageing of stem cells in terms of dysregulations of metabolism, aberrant activation of the immune system as well as promoting epigenetic instability of stem cell. In this concise review, we elucidate recent emerging topics on microbiotic alterations and underlying mechanisms in stem cell ageing.