Open AccessEffect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model
Author(s) -
Pluchino Nicola,
Poppi Giorgia,
Yart Lucile,
Marci Roberto,
Wenger JeanMarie,
Tille JeanChristophe,
Cohen Marie
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14372
Subject(s) - endometriosis , aromatase , anastrozole , chorioallantoic membrane , letrozole , aromatase inhibitor , embryo , estrogen , medicine , endometrium , biology , endocrinology , cancer research , microbiology and biotechnology , cancer , breast cancer
Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long‐term clinical use. An endometriosis‐targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue.