Open AccessAssociation of interleukin‐27 gene polymorphisms with susceptibility to HIV infection and disease progression
Author(s) -
Pang XiaoXia,
Luo ShunDa,
Zhang Ting,
Shi Feng,
Wang ChunFang,
Chen XingHong,
Wei YuXia,
Qin Li,
Wei JingXi,
Luo XiaoQiong,
Wang JunLi
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14067
Subject(s) - genotype , single nucleotide polymorphism , immunology , biology , polymorphism (computer science) , medicine , gastroenterology , gene , genetics
Interleukin‐27 ( IL ‐27) gene polymorphisms are linked to infectious disease susceptibility and IL ‐27 plasma level is associated with HIV infection. Therefore, we aimed to investigate the association between IL ‐27 polymorphisms and susceptibility to HIV infection and disease progression. A total of 300 patients with HIV infection (48 long‐term nonprogressors and 252 typical progressors) and 300 healthy controls were genotyped for three IL ‐27 polymorphisms, rs17855750, rs181206, rs40837 which were performed by using multiple single nucleotide primer extension technique. Significant association was found between IL ‐27 rs40837 polymorphisms with susceptibility to HIV infection ( AG vs AA : adjusted OR = 1.60, 95% CI , 1.11‐2.30, P = 0.012; AG + GG vs AA : adjusted OR = 1.44, 95% CI , 1.02‐2.03, P = 0.038) and disease progression ( LTNP : AG vs AA : adjusted OR = 2.33, 95% CI , 1.13‐4.80, P = 0.021; TP : AG vs AA : adjusted OR = 1.50, 95% CI , 1.04‐2.24, P = 0.030). Serum IL ‐27 levels were significantly lower in cases compared to controls ( P < 0.001). There were lower serum IL ‐27 levels in TP s than in LTNP s ( P < 0.001). We further found that LTNP s with rs40837 AG or GG genotype had lower serum IL ‐27 levels than with AA genotype ( P < 0.05). The CD 4 + T counts in cases were significantly lower than controls ( P < 0.001). In contrast, individuals with rs40837 AG genotype had lower CD 4 + T counts than with AA genotype in cases ( P < 0.05). In addition, CD 4 + T counts in TP s were significantly lower than LTNP s ( P < 0.001). IL ‐27 rs40837 polymorphism might influence the susceptibility to HIV infection and disease progression probably by regulating the level of serum IL ‐27 or the quantity of CD 4 + T.