Open AccessSignificance of plasma MACC 1 levels on the prognostic stratification in patients with colorectal cancer
Author(s) -
Lin Aifen,
Zhang RuiLi,
Zhang Xia,
He XiaoFang,
Zhang JianGang,
Yan WeiHua
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13989
Subject(s) - colorectal cancer , clinical significance , medicine , oncology , biomarker , metastasis , gastroenterology , cancer , chemistry , biochemistry
The clinical significance of metastasis‐associated in colon cancer‐1 (MACC1) has been investigated but the relevance of peripheral MACC1 levels was rather limited. Herein, our data revealed that plasma MACC1 levels in 117 colorectal cancer patients (CRC) were dramatically higher than that in normal controls ( P < 0.001), and with a strong discrimination power between the two groups (AUC = 0.960, P < 0.001). Moreover, MACC1 is an independent prognostic factor for CRC patients. When clinical parameters stratified by MACC1 low and MACC1 high , MACC1 levels exhibited further significant predictive value. Summary, plasma MACC1 levels could be a useful prognostic and diagnostic biomarker, and could improve the prognostic value of traditional prognosticators for colorectal cancer patients.