Open AccessMicro RNA s as regulators of cell death mechanisms in amyotrophic lateral sclerosis
Author(s) -
Gagliardi Delia,
Comi Giacomo P.,
Bresolin Nereo,
Corti Stefania
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13976
Subject(s) - necroptosis , amyotrophic lateral sclerosis , programmed cell death , rna , biology , apoptosis , microbiology and biotechnology , microrna , gene expression , neuroscience , gene , medicine , genetics , pathology , disease
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disorder affecting upper and lower motor neurons ( MN s), resulting in paralysis and precocious death from respiratory failure. Although the causes of ALS are incompletely understood, the role of alterations in RNA metabolism seems central. Micro RNA s (mi RNA s) are noncoding RNA s implicated in the regulation of gene expression of many relevant physiological processes, including cell death. The recent model of programmed cell death ( PCD ) encompasses different mechanisms, from apoptosis to regulated necrosis ( RN ), in particular necroptosis. Both apoptosis and necroptosis play a significant role in the progressive death of MN s in ALS . In this review, we present key research related to mi RNA s that modulate apoptosis and RN pathways in ALS . We also discuss whether these mi RNA s represent potential targets for therapeutic development in patients.