Open AccessDeciphering molecular properties of hypermutated gastrointestinal cancer
Author(s) -
Hu Wangxiong,
Yang Yanmei,
Ge Weiting,
Zheng Shu
Publication year - 2019
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13941
Subject(s) - biology , genetics , transcriptome , somatic hypermutation , cancer , genome , computational biology , gene , cancer research , gene expression , b cell , antibody
Abstract Great mutational heterogeneity is observed both across cancer types (>1000‐fold) and within a given cancer type, with a fraction harboring >10 mutations per million bases, thus termed hypermutation. We determined the genome‐wide effects of high mutation load on the transcriptome and methylome of two cancer types; namely, colorectal cancer ( CRC ) and stomach adenocarcinoma ( STAD ). Briefly, hierarchical clustering of the expression and methylation profiles showed that the majority of CRC and STAD hypermutated samples were mixed and separated from their respective non‐hypermutated samples, exceeding the boundary of tissue specificity. Further in‐detailed exploration uncovered that the underlying molecular mechanism may be related to the perturbation of chromatin remodeling genes.