Open AccessFunctional protection against cardiac diseases depends on ATP ‐sensitive potassium channels
Author(s) -
Ye Peng,
Zhu YanRong,
Gu Yue,
Zhang DaiMin,
Chen ShaoLiang
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13893
Subject(s) - cardioprotection , atp sensitive potassium channel , potassium channel , intracellular , microbiology and biotechnology , nitric oxide , pharmacology , chemistry , myocyte , ischemia , biology , biophysics , medicine , endocrinology , glibenclamide , diabetes mellitus
Abstract ATP ‐sensitive potassium channels ( K ATP ) channels are widely distributed in various tissues, including pancreatic beta cells, muscle tissue and brain tissue. K ATP channels play an important role in cardioprotection in physiological/pathological situations. K ATP channels are inhibited by an increase in the intracellular ATP concentration and are stimulated by an increase in the intracellular Mg ADP concentration. Activation of K ATP channels decreases ischaemia/reperfusion injury, protects cardiomyocytes from heart failure, and reduces the occurrence of arrhythmias. K ATP channels are involved in various signalling pathways, and their participation in protective processes is regulated by endogenous signalling molecules, such as nitric oxide and hydrogen sulphide. K ATP channels may act as a new drug target to fight against cardiovascular disease in the development of related drugs in the future. This review highlights the potential mechanisms correlated with the protective role of K ATP channels and their therapeutic value in cardiovascular diseases.