Open AccessSecretion of heat shock ‐60, ‐70 kD protein, IL ‐1β and TNF α levels in serum of a term normal pregnancy and patients with pre‐eclampsia development
Author(s) -
ÁlvarezCabrera María C.,
BarrientosGaleana Edgar,
BarreraGarcía Asyadette,
OsorioCaballero Mauricio,
Acevedo Jesús F.,
FloresHerrera Oscar,
Díaz Néstor F.,
MolinaHernández Anayansí,
GarcíaLópez Guadalupe,
FloresHerrera Héctor
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13824
Subject(s) - medicine , endocrinology , preeclampsia , transaminase , heat shock protein , lactate dehydrogenase , pregnancy , extracellular , amniotic fluid , hsp70 , chemistry , biology , fetus , biochemistry , enzyme , genetics , gene
The extracellular heat shock proteins ( eH sp) family act as molecular chaperones regulating folding, transporting protein and are associated with immune modulation in different physiological and pathological processes. They have been localized in different gestational tissues and their concentration in amniotic fluid and serum has been determined. In the present study, we proposed to determine the concentration of eH sp‐60, ‐70, IL ‐1β and TNF α in the serum of pregnant patients with 34 weeks of gestation with and without clinical evidences of preeclampsia ( PE ). Our results indicate significant increase of these markers in patients with PE with respect to healthy pregnant patients without active labor. Finally, the concentration of eH sp‐60 and ‐70 correlated positively with the hepatic dysfunction markers uric acid, lactate dehydrogenase ( LDH ), glutamic oxaloacetic transaminase (GOT) glutamic pyruvic transaminase (GPT), and inflammatory IL ‐1β and TNF α response. In conclusion, our results demonstrate a strong associated between Hsp and marker of hepatic dysfunction.