Open AccessLINC 01287 regulates tumorigenesis and invasion via miR‐298/ MYB in hepatocellular carcinoma
Author(s) -
Mo Yichao,
He Longguang,
Lai Zeru,
Wan Zhiheng,
Chen Qinshou,
Pan Sibo,
Li Liangfu,
Li Dasheng,
Huang Junwei,
Xue Fan,
Che Siyao
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13818
Subject(s) - myb , hepatocellular carcinoma , oncogene , long non coding rna , cancer research , carcinogenesis , biology , in vivo , rna , in vitro , cell , gene expression , cancer , cell cycle , gene , genetics
Recently, it was reported that long non‐coding RNA s (lnc RNA s) participated in promoting hepatocellular carcinoma ( HCC ) initiation and progression. Herein, we reported that the expression level of LINC 01287 was elevated in HCC cell lines and tissues. LINC 01287 down‐regulation inhibited HCC cells growth and invasion both in vitro and in vivo. LINC 01287 exerted as a ce RNA and negatively regulated miR‐298 expression. MYB was identified as a downstream target of miR‐298. The miR‐298/ MYB axis mediated LINC 01287's effect on HCC . To the best of our knowledge, our findings provided the first evidence that LINC 01287 functioned as an oncogene in HCC . LINC 01287 may be a candidate prognostic biomarker and a target for new therapies in HCC patients.