Open AccessThe emerging role of miR‐19 in glioma
Author(s) -
Wang Weihan,
Zhang Anling,
Hao Yubing,
Wang Guangxiu,
Jia Zhifan
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13788
Subject(s) - glioma , pathogenesis , cancer research , microrna , apoptosis , biology , radiation therapy , gene , medicine , immunology , genetics
Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of mi RNA s in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.