Open AccessThe non‐coding RNA OTUB 1‐isoform2 promotes ovarian tumour progression and predicts poor prognosis
Author(s) -
Wang Shunni,
Ning Yan,
Wei Ping,
Cai Dongliag,
Lu Linghui,
Li Jing,
Wang Yiqin
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13733
Subject(s) - ovarian cancer , cancer research , metastasis , oncogene , biology , malignancy , cancer , biomarker , medicine , oncology , cell cycle , biochemistry
Ovarian cancer is the leading malignancy of the female reproductive system and is associated with inconspicuous early invasion and metastasis. We have previously reported that the oncogene OTUB 1 plays a crucial role in ovarian cancer progression, but the role of its isoform, the non‐coding RNA OTUB 1‐isoform2, in ovarian cancer is still elusive. Here, we reported that OTUB 1‐isoform2 expression in ovarian cancer tissues was significantly higher than that in the paired paratumorous tissues ( P < .01). The patients with high expression of OTUB 1‐isoform2 had larger tumours than those with low expression ( P < .05). The high expression of OTUB 1‐isoform2 was correlated with the involvement of bilateral ovaries ( P < .05), lymph node metastasis ( P < .05), vascular invasion ( P < .05), greater omentum involvement ( P < .01), fallopian tube involvement ( P < .05), advanced FIGO stages ( P < .01) and recurrence ( P < .01). Moreover, OTUB 1‐isoform2 served as an independent negative prognostic predictor for disease‐free survival ( DFS ) and disease‐specific survival ( DSS ). Overexpression of OTUB 1‐isoform2 in the ovarian cancer cells stimulated cell proliferation, migration and invasion both in vitro and in vivo. In summary, our study suggested that OTUB 1‐isoform2 is a novel prognostic biomarker with independent oncogenic functions for ovarian cancer.