Open AccessPeptidylarginine deiminase 4 concentration, but not PADI 4 polymorphisms, is associated with ICU mortality in septic shock patients
Author(s) -
Costa Nara Aline,
Gut Ana Lúcia,
Azevedo Paula Schmidt,
Polegato Bertha Furlan,
Magalhães Eloá Siqueira,
Ishikawa Larissa Lumi Watanabe,
Bruder Rita de Cassia Siqueira,
Silva Evelyn Aparecida da,
Gonçalves Renan Braga,
Tanni Suzana Erico,
Rogero Marcelo Macedo,
Norde Marina Maintinguer,
Cunha Natália Baraldi,
Zornoff Leonardo Antonio Mamede,
Paiva Sergio Alberto Rupp,
Minicucci Marcos Ferreira
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13717
Subject(s) - medicine , septic shock , intensive care unit , logistic regression , mortality rate , apache ii , gastroenterology , sepsis
The objective of our study was to evaluate the association between peptidylarginine deiminase 4 ( PAD 4) concentration and its polymorphisms with mortality in patients with septic shock . We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit ( ICU ) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD 4 concentrations and its polymorphism PADI 4 _89 [ rs 11203366], PADI 4 _94 [ rs 2240340] and PADI 4 _104 [ rs 1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD 4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment ( SOFA ) scores. In addition, PAD 4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI 4 polymorphisms and ICU mortality. In the logistic regression models, PAD 4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate ( OR : 1.477; CI 95%: 1.186‐1.839; P < .001), and when adjusted for age, gender and APACHE II score ( OR : 1.392; CI 95%: 1.145‐1.692; P < .001). In conclusion, PAD 4 concentration, but not PADI 4 _89, PADI 4 _94 and PADI 4 _104 polymorphisms, is associated with ICU mortality in septic shock patients.