Open AccessThe regulatory role of micro RNA s in angiogenesis‐related diseases
Author(s) -
Sun LiLi,
Li WenDong,
Lei FengRui,
Li XiaoQiang
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13700
Subject(s) - angiogenesis , rna , cancer research , long non coding rna , non coding rna , neovascularization , biology , gene , genetics
Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a post‐transcriptional level via either the degradation or translational repression of a target mRNA . They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis‐related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of mi RNA s and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of mi RNA s in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between mi RNA s and angiogenesis, and mi RNA ‐based biomarkers in the diagnosis, treatment and prognosis of angiogenesis‐related diseases, providing an update on the understanding of the clinical value of mi RNA s in targeting angiogenesis.