Open AccessExosomes, the message transporters in vascular calcification
Author(s) -
Zhang Chao,
Zhang Kun,
Huang Feifei,
Feng Weijing,
Chen Jie,
Zhang Huanji,
Wang Jingfeng,
Luo Pei,
Huang Hui
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13692
Subject(s) - microvesicles , vascular smooth muscle , calcification , microbiology and biotechnology , medicine , extracellular matrix , cancer research , microrna , chemistry , biology , pathology , smooth muscle , gene , biochemistry
Vascular calcification ( VC ) is caused by hydroxyapatite deposition in the intimal and medial layers of the vascular wall, leading to severe cardiovascular events in patients with hypertension, chronic kidney disease and diabetes mellitus. VC occurrences involve complicated mechanism networks, such as matrix vesicles or exosomes production, osteogenic differentiation, reduced cell viability, aging and so on. However, with present therapeutic methods targeting at VC ineffectively, novel targets for VC treatment are demanded. Exosomes are proven to participate in VC and function as initializers for mineral deposition. Secreted exosomes loaded with micro RNA s are also demonstrated to modulate VC procession in recipient vascular smooth muscle cells. In this review, we targeted at the roles of exosomes during VC , especially at their effects on transporting biological information among cells. Moreover, we will discuss the potential mechanisms of exosomes in VC .