Open AccessLinc00483 as ce RNA regulates proliferation and apoptosis through activating MAPK s in gastric cancer
Author(s) -
Li Defeng,
Yang Meifeng,
Liao Aijun,
Zeng Bing,
Liu Diqun,
Yao Yuhong,
Hu Guangsheng,
Chen Xuanmin,
Feng Zhiqiang,
Du Yanlei,
Zhou Youlian,
He Jie,
Nie Yuqiang
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13661
Subject(s) - cancer , carcinogenesis , cancer research , downregulation and upregulation , metastasis , mapk/erk pathway , cancer cell , biology , long non coding rna , suppressor , signal transduction , cell growth , immunology , microbiology and biotechnology , genetics , gene
Long non‐coding RNA s (lnc RNA s) are important regulators of many cellular processes, and their aberrant expression and/or function is associated with many different diseases, including cancer. However, the identification of functional lnc RNA s in gastric cancer is still a challenge. In this study, we describe a novel functional lnc RNA , linc00483, that is upregulated and associated with tumorigenesis, tumour size, metastasis and poor prognosis in gastric cancer. In our study, linc00483 promoted gastric cancer cell proliferation, invasiveness and metastasis in vitro and in vivo. Mechanistically, upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR‐30a‐3p. Furthermore, it restores SPAG 9 expression, which is negatively regulated by miR‐30a‐3p, and actives MAPK signaling pathway in gastric cancer cells. Thus, linc00483 is an oncogenic lnc RNA in gastric cancer and targeting linc00483 or its pathway can potentially be useful in development of targeted therapies for patients with gastric cancer. Our results show that linc00483 is an important regulator in carcinogenesis and may be a useful biomarker to predict prognosis of gastric cancer patients. We believe our findings are novel and will be of interest to scientists working in many areas related to biomarkers in cancer.