Open AccessCrosstalk between long non‐coding RNA s and Wnt/β‐catenin signalling in cancer
Author(s) -
Yang Gang,
Shen Tianyi,
Yi Xiaoming,
Zhang Zhengyu,
Tang Chaopeng,
Wang Longxin,
Zhou Yulin,
Zhou Wenquan
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13522
Subject(s) - wnt signaling pathway , biology , rna , crosstalk , carcinogenesis , long non coding rna , non coding rna , cancer research , signal transduction , catenin , microbiology and biotechnology , computational biology , cancer , genetics , gene , physics , optics
Long non‐coding RNA s (lnc RNA s) are non‐protein‐coding transcripts in the human genome which perform crucial functions in diverse biological processes. The abnormal expression of some lnc RNA s has been found in tumorigenesis, development and therapy resistance of cancers. They may act as oncogenes or tumour suppressors and can be used as diagnostic or prognostic markers, prompting their therapeutic potentials in cancer treatments. Studies have indicated that many lnc RNA s are involved in the regulation of several signal pathways, including Wnt/β‐catenin signalling pathway, which has been reported to play a significant role in regulating embryogenesis, cell proliferation and controlling tumour biology. Emerging evidences have suggested that lnc RNA s can interact with several components of the Wnt/β‐catenin signalling pathway to regulate the expression of Wnt target genes in cancer. Moreover, the expression of lnc RNA s can also be influenced by the pathway. Nevertheless, Wnt/β‐catenin signalling pathway‐related lnc RNA s and their interactions in cancer are not systematically analysed before. Considering these, this review emphasized the associations between lnc RNA s and Wnt/β‐catenin signalling pathway in cancer initiation, progression and their therapeutic influence. We also provided an overview on characteristics of lnc RNA s and Wnt/β‐catenin signalling pathway and discussed their functions in tumour biology. Finally, targeting lnc RNA s or/and molecules associated with the Wnt/β‐catenin signalling pathway may be a feasible therapeutic method in the future.