Open AccessAssociation of lipoprotein‐associated phospholipase A2 mass with asymptomatic cerebral artery stenosis
Author(s) -
Wang Youxin,
Zhou Bin,
Zhou Pingan,
Yao Yan,
Cui Qinghua,
Liu Yingping,
Yang Jichun,
Wu Shouling,
Zhao Xingquan,
Zhou Yong
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13521
Subject(s) - medicine , interquartile range , asymptomatic , odds ratio , quartile , body mass index , lipoprotein associated phospholipase a2 , stenosis , cardiology , confidence interval , stroke (engine) , gastroenterology , lipoprotein , cholesterol , mechanical engineering , engineering
Cerebral artery stenosis ( CAS ) is the most important causes of ischaemic stroke. Lipoprotein‐associated phospholipase A2 (Lp‐ PLA 2) plays 2 diverse roles in atherosclerosis (pro‐inflammatory and anti‐inflammatory), and the association between Lp‐ PLA 2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross‐sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010‐2011 to investigate whether Lp‐ PLA 2 mass is associated with asymptomatic cerebral artery stenosis ( ACAS ). Serum Lp‐ PLA 2 mass was determined by enzyme‐linked immunosorbent assay ( ELISA ). All participants underwent transcranial Doppler ( TCD ) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis ( ICAS ) and extracranial arterial stenosis ( ECAS ). The median serum Lp‐ PLA 2 mass of the participants was 140.74 ng/mL (interquartile range: 131.79‐158.07 ng/ mL ). The adjusted odds ratio ( OR ) when comparing the 4th quartile to the 1st quartile of Lp‐ PLA 2 was 1.98 (95% confidence interval ( CI ): 1.42‐2.78), 1.79 (95% CI : 1.08‐2.94) and 1.87 (95% CI : 1.28‐2.73) for the occurrence of ACAS , asymptomatic ECAS and asymptomatic ICAS , respectively, after controlling for vascular risk factors. These independently significant associations remained statistically significant in the male or elderly subgroups, but not in females or middle‐aged participants. Lp‐ PLA 2 mass is positively correlated with subclinical atherosclerosis determined by ACAS , ICAS and ECAS in North Chinese, particularly in male and older participants, suggesting that serum Lp‐ PLA 2 mass might be potential biomarker for the detection of ACAS in the adults.