Open AccessFibromodulin reduces scar size and increases scar tensile strength in normal and excessive‐mechanical‐loading porcine cutaneous wounds
Author(s) -
Jiang Wenlu,
Ting Kang,
Lee Soonchul,
Zara Janette N.,
Song Richard,
Li Chenshuang,
Chen Eric,
Zhang Xinli,
Zhao Zhihe,
Soo Chia,
Zheng Zhong
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13516
Subject(s) - extracellular matrix , medicine , hypertrophic scar , wound healing , ultimate tensile strength , extracellular , dermatology , pathology , surgery , biology , microbiology and biotechnology , materials science , metallurgy
Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive‐mechanical‐loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix ( ECM ) molecule—fibromodulin ( FMOD ) protein—can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive‐mechanical‐loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD ‐based technologies hold high translational potential and applicability to human patients suffering from scarring—especially hypertrophic scarring.