Open AccessThe emerging role of long non‐coding RNA in spinal cord injury
Author(s) -
Shi Zhongju,
Pan Bin,
Feng Shiqing
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13515
Subject(s) - spinal cord injury , long non coding rna , biogenesis , mechanism (biology) , neuroscience , astrocyte , microglia , medicine , bioinformatics , malat1 , spinal cord , biology , rna , central nervous system , immunology , inflammation , gene , genetics , philosophy , epistemology
Abstract Spinal cord injury ( SCI ) is a significant health burden worldwide which causes permanent neurological deficits, and there are approximately 17,000 new cases each year. However, there are no effective and current treatments that lead to functional recovery because of the limited understanding of the pathogenic mechanism of SCI . In recent years, the biological roles of long non‐coding RNA s (lnc RNA s) in SCI have attracted great attention from the researchers all over the world, and an increasing number of studies have investigated the regulatory roles of lnc RNA s in SCI . In this review, we summarized the biogenesis, classification and function of lnc RNA s and focused on the investigations on the roles of lnc RNA s involved in the pathogenic processes of SCI , including neuronal loss, astrocyte proliferation and activation, demyelination, microglia activation, inflammatory reaction and angiogenesis. This review will help understand the molecular mechanisms of SCI and facilitate the potential use of lnc RNA s as diagnostic markers and therapeutic targets for SCI treatment.