Open AccessPhysical exosome:exosome interactions
Author(s) -
BeitYannai Elie,
Tabak Saray,
Stamer W. Daniel
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13479
Subject(s) - exosome , microvesicles , microbiology and biotechnology , extracellular , intracellular , signalling , extracellular vesicles , biology , chemistry , microrna , biochemistry , gene
Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome–exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome‐mediated signalling. We discuss experiments to test this hypothesis and potential relevance in health and disease.