Open AccessAssociation between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders
Author(s) -
Wigner Paulina,
Czarny Piotr,
Synowiec Ewelina,
Bijak Michał,
Białek Katarzyna,
Talarowska Monika,
Galecki Piotr,
Szemraj Janusz,
Sliwinski Tomasz
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13459
Subject(s) - genotype , allele , tph2 , single nucleotide polymorphism , genetics , biology , microbiology and biotechnology , tryptophan hydroxylase , heterozygote advantage , gene , serotonin , receptor , serotonergic
Tryptophan catabolites pathway disorders are observed in patients with depression. Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate the risk of depression occurrence. The objective of our study was to confirm the association between the presence of polymorphic variants of TPH 1 and TPH 2 genes, and the development of depressive disorders. Six polymorphisms were selected: c.804‐7C>A (rs10488682), c.‐1668T>A (rs623580), c.803+221C>A (rs1800532), c.‐173A>T (rs1799913)— TPH 1 , c.‐1449C>A (rs7963803), and c.‐844G>T (rs4570625)— TPH 2 . A total of 510 DNA samples (230 controls and 280 patients) were genotyped using TaqMan probes. Among the studied polymoorphisms, the G/G genotype and G allele of c.804‐7C>A— TPH 1 , the T/T homozygote of c.803+221C>A— TPH 1 , the A/A genotype and A allele of c.1668T>A— TPH 1 , the G/G homozygote and G allele of c.‐844G>T— TPH 2 , and the C/A heterozygote and A allele of c.‐1449C>A— TPH 2 were associated with the occurrence of depression. However, the T/T homozygote of c.‐1668T>A— TPH 1 , the G/T heterozygote and T allele of c.‐844G>T— TPH 2 , and the C/C homozygote and C allele of c.‐1449C>A— TPH 2 decreased the risk of development of depressive disorders . Each of the studied polymorphisms modulated the risk of depression for selected genotypes and alleles. These results support the hypothesis regarding the involvement of the pathway in the pathogenesis of depression.