Open AccessDihydroartemisinin up‐regulates VE ‐cadherin expression in human renal glomerular endothelial cells
Author(s) -
Li Liqun,
Chen Xiaocui,
Dong Fengyun,
Liu Qiang,
Zhang Caiqing,
Xu Dongmei,
Allen Thaddeus D.,
Liu Ju
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13448
Subject(s) - ve cadherin , dihydroartemisinin , cadherin , snail , slug , microbiology and biotechnology , effector , biology , cancer research , immunology , biochemistry , artemisinin , malaria , ecology , cell , plasmodium falciparum
The antimalarial agent dihydroartemisinin ( DHA ) has been shown to be anti‐inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial ( VE )‐cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF ‐β RI ‐Smad2/3 signalling and its downstream effectors SNAIL and SLUG , which repress VE ‐cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE ‐cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE ‐cadherin expression.