ALDH 2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Several studies indicate the mitochondrial Aldehyde Dehydrogenase‐2 ( ALDH 2) gene G487A polymorphism may be correlated with coronary artery disease ( CAD ) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH 2 gene G487A polymorphism and CAD within the Chinese population, a meta‐analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios ( OR s) and their corresponding 95% confidence intervals were assessed using random or fixed‐effect models depending the heterogeneity existence or not. Our meta‐analysis found a significant association between ALDH 2 gene G487A polymorphism and CAD in the Chinese population under allele ( OR : 1.830, 95% CI : 1.560–2.140, P = 1.36 × 10 −13 ), recessive ( OR : 1.920, 95% CI : 1.530–2.390, P = 1.20 × 10 −8 ), dominant ( OR : 1.593, 95% CI : 1.336–1.900, P = 2.22 × 10 −7 ), homozygous ( OR : 2.280, 95% CI : 1.810–2.870, P = 3.17 × 10 −12 ) and heterozygous genetic models ( OR : 3.330, 95% CI : 2.070–5.370, P = 7.81 × 10 −7 ). The positive correlation between the ALDH 2 gene G487A polymorphism and CAD makes the mutation a strong candidate as a genetic risk marker for CAD . Through further analysis, we also found that A allele carriers of ALDH 2 gene G487A polymorphism may be particularly susceptible to CAD .