Open AccessALDH 2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants
Author(s) -
Li Yanyan,
Wang Hui,
Wu Jingjing,
Kim Hyun Jun,
Yang Xinxing,
Geng Hongyu,
Gong Ge
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13443
Subject(s) - aldehyde dehydrogenase , allele , meta analysis , coronary artery disease , odds ratio , genetics , biology , polymorphism (computer science) , population , gene polymorphism , medicine , gene , gastroenterology , environmental health
Several studies indicate the mitochondrial Aldehyde Dehydrogenase‐2 ( ALDH 2) gene G487A polymorphism may be correlated with coronary artery disease ( CAD ) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH 2 gene G487A polymorphism and CAD within the Chinese population, a meta‐analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios ( OR s) and their corresponding 95% confidence intervals were assessed using random or fixed‐effect models depending the heterogeneity existence or not. Our meta‐analysis found a significant association between ALDH 2 gene G487A polymorphism and CAD in the Chinese population under allele ( OR : 1.830, 95% CI : 1.560–2.140, P = 1.36 × 10 −13 ), recessive ( OR : 1.920, 95% CI : 1.530–2.390, P = 1.20 × 10 −8 ), dominant ( OR : 1.593, 95% CI : 1.336–1.900, P = 2.22 × 10 −7 ), homozygous ( OR : 2.280, 95% CI : 1.810–2.870, P = 3.17 × 10 −12 ) and heterozygous genetic models ( OR : 3.330, 95% CI : 2.070–5.370, P = 7.81 × 10 −7 ). The positive correlation between the ALDH 2 gene G487A polymorphism and CAD makes the mutation a strong candidate as a genetic risk marker for CAD . Through further analysis, we also found that A allele carriers of ALDH 2 gene G487A polymorphism may be particularly susceptible to CAD .