Open AccessRelative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese
Author(s) -
Wu LongFei,
Zhu DongCheng,
Wang BingHua,
Lu YiHua,
He Pei,
Zhang YunHong,
Gao HongQin,
Zhu XiaoWei,
Xia Wei,
Zhu Hong,
Mo XingBo,
Lu Xin,
Zhang Lei,
Zhang YongHong,
Deng FeiYan,
Lei ShuFeng
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13438
Subject(s) - myostatin , bone mineral , endocrinology , medicine , biology , skeletal muscle , abundance (ecology) , bone resorption , chemistry , osteoporosis , ecology
Myostatin is mainly secreted by skeletal muscle and negatively regulates skeletal muscle growth. However, the roles of myostatin on bone metabolism are still largely unknown. Here, we recruited two large populations containing 6308 elderly Chinese and conducted comprehensive statistical analyses to evaluate the associations among lean body mass ( LBM ), plasma myostatin, and bone mineral density ( BMD ). Our data revealed that total myostatin in plasma was mainly determined by LBM . The relative abundance of mature myostatin (mature/total) was significantly lower in high versus low BMD subjects. Moreover, the relative abundance of mature myostatin was positively correlated with bone resorption marker. Finally, we carried out in vitro experiments and found that myostatin has inhibitory effects on the proliferation and differentiation of human osteoprogenitor cells. Taken together, our results have demonstrated that the relative abundance of mature myostatin in plasma is negatively associated with BMD , and the underlying functional mechanism for the association is most likely through inhibiting osteoblastogenesis and promoting osteoclastogenesis.