Open AccessTherapeutic application of extracellular vesicles in kidney disease: promises and challenges
Author(s) -
Lv LinLi,
Wu WeiJun,
Feng Ye,
Li ZuoLin,
Tang TaoTao,
Liu BiCheng
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13407
Subject(s) - extracellular vesicles , nephron , kidney disease , kidney , vesicle , regeneration (biology) , microbiology and biotechnology , acute kidney injury , disease , extracellular , medicine , pharmacology , biology , chemistry , cancer research , pathology , membrane , biochemistry
Extracellular vesicles ( EV s) are nanosized, membrane‐bound vesicles released from different cells. Recent studies have revealed that EV s may participate in renal tissue damage and regeneration through mediating inter‐nephron communication. Thus, the potential use of EV s as therapeutic vector has gained considerable interest. In this review, we will discuss the basic characteristics of EV s and its role in nephron cellular communication. Then, the application of EV s as therapeutic vector based on its natural content or as carriers of drug, in acute and chronic kidney injury, was discussed. Finally, perspectives and challenges of EV s in therapy of kidney disease were described.