Open AccessIntegrin β‐3 is required for the attachment, retention and therapeutic benefits of human cardiospheres in myocardial infarction
Author(s) -
Liu Suyun,
Jiang Zhian,
Qiao Li,
Guo Bingyan,
Xiao Wenliang,
Zhang Xiaoguang,
Chang Liang,
Li Yongjun
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13325
Subject(s) - myocardial infarction , stem cell , medicine , regeneration (biology) , stem cell therapy , integrin , cell therapy , cardiology , cell , heart failure , mesenchymal stem cell , cancer research , microbiology and biotechnology , pathology , biology , receptor , biochemistry
Abstract Cardiovascular diseases remain the leading causes of death worldwide. Stem cell therapy offers a promising option to regenerate injured myocardium. Among the various types of stem cells, cardiosphere cells represent a mixture of intrinsic heart stem cells and supporting cells. The safety and efficacy of cardiosphere cells have been demonstrated in recent clinical trials. Cell–matrix interaction plays an important role in mediating the engraftment of injected stem cells. Here, we studied the role of integrin β‐3 in cardiosphere‐mediated cell therapy in a mouse model of myocardial infarction. Our results indicated that inhibiting integrin β‐3 reduced attachment, retention and therapeutic benefits of human cardiospheres in mice with acute myocardial infarction. This suggests integrin β‐3 plays an important role in cardiosphere‐mediated heart regeneration.