Open AccessExpression signatures and roles of Micro RNA s in human oesophageal adenocarcinomas
Author(s) -
Kong Xiangyi,
Gong Shun,
Su Lijuan,
Li Chen,
Kong Yanguo
Publication year - 2018
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13300
Subject(s) - malignancy , rna , cancer research , adenocarcinoma , biology , long non coding rna , cancer , microrna , cell , gene , genetics
The most common forms of oesophageal cancers are adenocarcinomas and squamous cell carcinoma ( SCC ). Although the incidence of SCC in the United States tends to be declining, the adenocarcinoma incidence caused by Barrett's oesophagus has been increasing. Oesophageal cancer is regarded as one of the most fatal malignancies with a short prognosis. Systemic manifestations of patients with PCNSL keep backward in spite of recent development of chemoradiotherapy. Micro RNA s are small non‐coding RNA s that can post‐transcriptionally down‐regulate the expression of genes by targeting mRNA s, causing their translational repression as well as degradation. Micro RNA s exert critical functions in many malignancy‐related biological processes, including cell apoptosis, metabolism, proliferation and differentiation. Many deregulated mi RNA s have been identified in oesophageal adenocarcinomas, but their biological importance has not yet been fully elucidated. In this study, we review present evidence regarding the potential applications of oesophageal adenocarcinomas associated micro RNA s for prognosis and diagnosis of this lethal disease.