Open AccessRoles of ST 2, IL ‐33 and BNP in predicting major adverse cardiovascular events in acute myocardial infarction after percutaneous coronary intervention
Author(s) -
Wang YanPeng,
Wang JianHua,
Wang XiaoLong,
Liu JunYi,
Jiang FangYun,
Huang XiaoLi,
Hang JingYu,
Qin Wei,
Ma ShiXin,
Zhang Jie,
Yuan MinJie,
Li JingBo,
Lu ZhiGang,
Wei Meng
Publication year - 2017
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.13183
Subject(s) - medicine , myocardial infarction , percutaneous coronary intervention , cardiology , conventional pci , receiver operating characteristic
This study investigated roles of serum ST 2, IL ‐33 and BNP in predicting major adverse cardiovascular events ( MACE s) in acute myocardial infarction ( AMI ) after percutaneous coronary intervention ( PCI ). Blood samples were collected from the included AMI patients ( n = 180) who underwent PCI . All patients were divided into the MACE s and MACE s‐free groups. Enzyme‐linked immunosorbent assay was performed to measure serum levels of ST 2, IL ‐33 and BNP . Severity of coronary artery lesion was evaluated by Gensini score. Pearson correlation analysis was used. A receiver operating characteristics curve was drawn to evaluate the potential roles of ST 2, IL ‐33 and BNP in predicting MACE s, and Kaplan–Meier curve to analyse the 1‐year overall survival rate. Logistic regression analysis was conducted to analyse the independent risk factors for MACE s. Compared with the MACE s‐free group, the serum levels of ST 2, IL ‐33 and BNP were significantly higher in the MACE s group. Serum levels of ST 2, IL ‐33 and BNP were positively correlated with each other and positively correlated with Gensini score. The area under curves of ST 2, IL ‐33 and BNP , respectively, were 0.872, 0.675 and 0.902. The relative sensitivity and specificity were, respectively, 76.27% and 85.92%, 69.49% and 58.68%, as well as, 96.61% and 77.69%. Serum levels of ST 2, IL ‐33 and BNP were independent risk factors for MACE s. The 1‐year overall survival rate was higher in AMI patients with lower serum levels of ST 2, IL ‐33 and BNP . In conclusion, serum levels of ST 2, IL ‐33 and BNP have potential value in predicting MACE s in AMI patients undergoing PCI .