Open AccessRETRACTED: Micro RNA ‐379 suppresses osteosarcoma progression by targeting PDK 1
Author(s) -
Li Zheng,
Shen Jianxiong,
Chan Matthew T. V.,
Wu William Ka Kei
Publication year - 2017
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12966
Subject(s) - osteosarcoma , cancer research , cell growth , rna , microrna , cell , in vivo , chemistry , biology , microbiology and biotechnology , gene , genetics
Osteosarcoma is the most common primary bone tumour. Increasing evidence has demonstrated the pathogenic role of micro RNA (mi RNA s) dysregulation in tumour development. miR‐379 was previously reported to function as an oncogenic or tumour‐suppressing mi RNA in a tissue‐dependent manner. However, its function in osteosarcoma remains unknown. In this study, we found that the expression of miR‐379 was downregulated in osteosarcoma tissues and cell lines. Further functional characterization revealed that miR‐379 suppressed osteosarcoma cell proliferation and invasion in vitro and retarded the growth of osteosarcoma xenografts in vivo . Mechanistically, PDK 1 was identified as the direct target of miR‐379 in osteosarcoma, in which PDK 1 expression was up‐regulated and showed inverse correlation with miR‐379. Enforced expression of PDK 1 promoted osteosarcoma cell proliferation and rescued the anti‐proliferative effect of miR‐379. These data suggest that miR‐379 could function as a tumour‐suppressing mi RNA via targeting PDK 1 in osteosarcoma.