Open AccessThe role of micro RNA s in intrahepatic cholangiocarcinoma
Author(s) -
Li Zheng,
Shen Jianxiong,
Chan Matthew T.V.,
Wu William Ka Kei
Publication year - 2017
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12951
Subject(s) - microrna , gene silencing , pathogenesis , competing endogenous rna , biology , intrahepatic cholangiocarcinoma , cancer research , metastasis , malignancy , rna , messenger rna , gene expression , gene , long non coding rna , bioinformatics , pathology , medicine , immunology , cancer , genetics
Abstract Intrahepatic cholangiocarcinoma ( ICC ) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. Micro RNA s (mi RNA s) are a class of highly conserved, endogenous, small non‐coding RNA molecules of 18–23 nucleotides in length, which regulate gene expression through complementary base‐pairing with target messenger RNA s and subsequent gene silencing. Several studies have shown deregulated expression of mi RNA s in ICC cell lines and tissues, in which these mi RNA s play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of mi RNA in the pathogenesis of ICC and explore the possibilities of using mi RNA s as prognostic and diagnostic markers, as well as therapeutic targets in ICC .