Open AccessTGF ‐β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta‐analysis
Author(s) -
Shen ZeTian,
Shen JunShu,
Ji XiaoQin,
Li Bing,
Zhu XiXu
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12933
Subject(s) - odds ratio , meta analysis , medicine , confidence interval , gastroenterology , lung cancer , genotype , oncology , pneumonitis , polymorphism (computer science) , radiation pneumonitis , biology , genetics , lung , gene
Transforming growth factor beta 1( TGF ‐ β1 ) polymorphism was associated with radiation pneumonitis ( RP ) susceptibility, but their results have been inconsistent. The PubMed and CNKI were searched for case‐control studies published up to Januray 01, 2016 was Data were extracted and pooled odds ratios ( OR ) with 95% confidence intervals ( CI ) were calculated. In this meta‐analysis, we assessed eight publications involving 368 radiation pneumonitis cases and 855 controls of the association between TGF ‐β1 T869C (rs1982073) and G915C (rs1800471) polymorphism and RP susceptibility. Our analysis suggested that TGF ‐β1 T869C rs1982073 polymorphism was associated with lower RP risk for CT combined CC versus TT model ( OR = 0.58, 95% CI = 0.43–0.77). However, for the G915C rs1800471 polymorphism, no association was found between the polymorphism and the susceptibility to RP in GC combined CC versus GG model ( OR = 0.82, 95% CI = 0.50–1.35). These results from the meta‐analysis suggest that T869C rs1982073 polymorphism of TGF ‐β1 may be associated with RP risk, and there may be no association between G915C polymorphism and RP risk.