Open AccessThe role of BRD 7 in embryo development and glucose metabolism
Author(s) -
Kim Yoo,
Andrés Salazar Hernández Mario,
Herrema Hilde,
Delibasi Tuncay,
Park Sang Won
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12907
Subject(s) - bromodomain , biology , embryo , gene knockdown , embryogenesis , metabolism , microbiology and biotechnology , epigenetics , genetics , endocrinology , gene
Bromodomain‐containing protein 7 ( BRD 7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD 7 plays a role in metabolic processes. However, the effect of BRD 7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD 7 during embryo development. Mice homozygous for BRD 7 led to embryonic lethality at mid‐gestation. Homozygous BRD 7 knockout ( KO ) mice showed retardation in development, and eventually all BRD 7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.