Open AccessThe insights of Let‐7 miRNAs in oncogenesis and stem cell potency
Author(s) -
Sun Xin,
Liu Jian,
Xu Chongwen,
Tang ShouChing,
Ren Hong
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12861
Subject(s) - carcinogenesis , microrna , stem cell , biology , potency , computational biology , cancer research , microbiology and biotechnology , genetics , cancer , gene , in vitro
The ability of the classic tumour‐suppressive let‐7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream‐targeted mRNA s, let‐7 affected most aspects of cell biology. It is perplexing how let‐7 affects oncogenesis, as the large influx of new mi RNA s and other kinds of non‐coding RNA s are continuously defined. In this review, we delineate the complex functions of let‐7 and discuss the future direction of let‐7 research.