Open AccessAnalysis of lipophilic fluorescent products in blood of Alzheimer's disease patients
Author(s) -
Chmátalová Zuzana,
Vyhnálek Martin,
Laczó Jan,
Hort Jakub,
Skoumalová Alice
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12824
Subject(s) - dementia , oxidative stress , lipid peroxidation , alzheimer's disease , disease , medicine , cognitive impairment , cognitive decline , pathology
Alzheimer's disease ( AD ) is a severe neurodegenerative disorder characterized by cognitive decline. Prodromal stage of AD , also called mild cognitive impairment ( MCI ), especially its amnestic type ( aMCI ), precedes dementia stage of AD . There are currently no reliable diagnostic biomarkers of AD in the blood. Alzheimer's disease is accompanied by increased oxidative stress in brain, which leads to oxidative damage and accumulation of free radical reaction end‐products. In our study, specific products of lipid peroxidation in the blood of AD patients were studied. Lipophilic extracts of erythrocytes ( AD dementia = 19, aMCI = 27, controls = 16) and plasma ( AD dementia = 11, aMCI = 17, controls = 16) were analysed by fluorescence spectroscopy. The level of these products is significantly increased in erythrocytes and plasma of AD dementia and aMCI patients versus controls. We concluded that oxidative stress end‐products are promising new biomarkers of AD , but further detailed characterisation of these products is needed.