Open AccessComparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types
Author(s) -
Song Dongli,
Cretoiu Dragos,
Zheng Minghuan,
Qian Mengjia,
Zhang Miaomiao,
Cretoiu Sanda M.,
Chen Luonan,
Fang Hao,
Popescu Laurentiu M.,
Wang Xiangdong
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12746
Subject(s) - biology , gene expression , gene , chromosome , cell type , cell , genetics , gene expression profiling , computational biology , microbiology and biotechnology
Telocytes ( TC s) are new cellular entities of mesenchymal origin described almost ubiquitously in human and mammalian organs ( www.telocytes.com ). Different subtypes of TC s were described, all forming networks in the interstitial space by homo‐ and heterocellular junctions. Previous studies analysed the gene expression profiles of chromosomes 1, 2, 3, 17 and 18 of murine pulmonary TC s. In this study, we analysed by bioinformatics tools the gene expression profiles of chromosome 4 for murine pulmonary TC s and compared it with mesenchymal stem cells ( MSC s), fibroblasts (Fbs), alveolar type II cells (ATII), airway basal cells, proximal airway cells, CD 8(+) T cells from bronchial lymph nodes (T‐ BL ) and CD 8(+) T cells from lungs (T‐L). Key functional genes were identified with the aid of the reference library of the National Center for Biotechnology Information Gene Expression Omnibus database. Seventeen genes were up‐regulated and 56 genes were down‐regulated in chromosome 4 of TC s compared with other cells. Four genes (Akap2, Gpr153, Sdc3 and Tbc1d2) were up‐regulated between one and fourfold and one gene, Svep1, was overexpressed over fourfold. The main functional networks were identified and analysed, pointing out to a TC s involvement in cellular signalling, regulation of tissue inflammation and cell expansion and movement.