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Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease
Author(s) -
DonateCorrea Javier,
MartínNúñez Ernesto,
MartínezSanz Rafael,
MurosdeFuentes Mercedes,
MoraFernández Carmen,
PérezDelgado Nayra,
NavarroGonzález Juan F.
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12710
Subject(s) - klotho , disease , pathogenesis , diabetes mellitus , incidence (geometry) , coronary artery disease , vascular disease , medicine , gene , pathophysiology , gene expression , bioinformatics , biology , endocrinology , genetics , kidney , physics , optics
Klotho protein has been associated with beneficial effects that contribute to the maintenance of cardiovascular health. Diverse studies suggest that alterations in the levels of this molecule may be associated with pathophysiological abnormalities that result in increased cardiovascular risk. The primary aim of this proof‐of‐concept study was to analyse the existence of a potential link between Klotho gene polymorphisms and the expression level of this gene in the vascular wall, and additionally with the incidence of cardiovascular disease and cardiovascular risk factors. Our results indicate that the variant G‐395A, located in the promoter region, influences Klotho gene vascular expression and is associated with the incidence of diabetes. Similarly, the exonic variant KL ‐ VS was associated with the incidence of atherosclerotic vascular disease and coronary artery disease. Moreover, vascular expression levels of Klotho were related with the incidence of diabetes mellitus and coronary artery disease. These findings, which need to be confirmed in larger studies, suggest a potential role of Klotho in the pathogenesis of vascular damage.

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