Open AccessThe perioperative time course and clinical significance of the chemokine CXCL 16 in patients undergoing cardiac surgery
Author(s) -
Dreymueller Daniela,
Goetzenich Andreas,
Emontzpohl Christoph,
Soppert Josefin,
Ludwig Andreas,
Stoppe Christian
Publication year - 2016
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12708
Subject(s) - perioperative , medicine , chemokine , cardiac surgery , cardiopulmonary bypass , pathogenesis , clinical significance , bypass surgery , cardiology , gastroenterology , inflammation , surgery , anesthesia , artery
The chemokine CXCL 16 and its receptor CXCR 6 have been linked to the pathogenesis of acute and chronic cardiovascular disease. However, data on the clinical significance of CXCL 16 in patients undergoing cardiac surgery with acute myocardial ischemia/reperfusion (I/R) are still lacking. Therefore, we determined CXCL 16 in the serum of cardiac surgery patients and investigated its kinetics and association with the extent of organ dysfunction. 48 patients underwent conventional cardiac surgery with myocardial I/R and the use of cardiopulmonary bypass ( CPB ) were consecutively enrolled in the present study. We investigated the peri‐ and post‐operative profile of CXCL 16. Clinical relevant data were assessed and documented throughout the entire observation period. To identify the influence of myocardial I/R and CPB on CXCL 16 release data were compared to those received from patients that underwent off‐pump procedure. Pre‐operative serum CXCL 16 levels were comparable to those obtained from healthy volunteers (1174 ± 55.64 pg/ml versus 1225 ± 70.94). However, CXCL 16 levels significantly increased during surgery (1174 ± 55.64 versus 1442 ± 75.42 pg/ml; P = 0.0057) and reached maximum levels 6 hrs after termination of surgery (1174 ± 55.64 versus 1648 ± 74.71 pg/ml; P < 0.001). We revealed a positive correlation between the intraoperative serum levels of CXCL 16 and the extent of organ dysfunction ( r 2 = 0.356; P = 0.031). Patients with high CXCL 16 release showed an increased extent of organ dysfunction compared to patients with low CXCL 16 release. Our study shows that CXCL 16 is released into the circulation as a result of cardiac surgery and that high post‐operative CXCL 16 levels are associated with an increased severity of post‐operative organ dysfunctions.