Open AccessMicro RNA s; easy and potent targets in optimizing therapeutic methods in reparative angiogenesis
Author(s) -
Pourrajab Fatemeh,
Vakili Zarch Abbas,
Hekmatimoghaddam Seyedhossein,
ZareKhormizi Mohamad Reza
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12669
Subject(s) - angiogenesis , senescence , rna , ischemia , therapeutic angiogenesis , stem cell , function (biology) , microbiology and biotechnology , biology , cancer research , disease , bioinformatics , medicine , neovascularization , pathology , biochemistry , gene
The age‐related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double‐edged sword in the development and prognosis of ischaemia‐associated diseases. Evidence evokes micro RNA s (mi RNA s) as molecular switchers that underlie cellular events in different tissues. Here, mi RNA s would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of mi RNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell‐based therapy.