Interferon‐α curbs production of interleukin‐22 by human peripheral blood mononuclear cells exposed to live  Borrelia burgdorferi | Zendy

Berner Anika | Zendy; Bachmann Malte | Zendy; Pfeilschifter Josef | Zendy; Kraiczy Peter | Zendy; Mühl Heiko | Zendy

Open Access

Interferon‐α curbs production of interleukin‐22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi

Author(s) -

Berner Anika,

Bachmann Malte,

Pfeilschifter Josef,

Kraiczy Peter,

Mühl Heiko

Publication year - 2015

Publication title -

journal of cellular and molecular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.44

H-Index - 130

eISSN - 1582-4934

pISSN - 1582-1838

DOI - 10.1111/jcmm.12634

Subject(s) - peripheral blood mononuclear cell , borrelia burgdorferi , peripheral blood , interferon γ , interferon , immunology , interleukin , virology , interferon gamma , peripheral , medicine , microbiology and biotechnology , biology , cytokine , antibody , in vitro , biochemistry

Cytokine networks initiated by means of innate immunity are regarded as a major determinant of host defence in response to acute infection by bacteria including Borrelia burgdorferi . Herein, we demonstrate that interferon ( IFN )‐α, either endogenously produced after exposure of cells to toll‐like receptor‐9‐activating CpG oligonucleotides or provided as recombinant cytokine, weakens activation of the anti‐bacterial interleukin ( IL )‐1/ IL ‐22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi . As IFN ‐α has been related to pathological dissemination of the spirochaete, data suggest an immunoregulatory role of type I IFN in this context that is able to significantly modify cytokine profiles thereby possibly determining early course of B. burgdorferi infection.

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