Open AccessInterferon‐α curbs production of interleukin‐22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi
Author(s) -
Berner Anika,
Bachmann Malte,
Pfeilschifter Josef,
Kraiczy Peter,
Mühl Heiko
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12634
Subject(s) - peripheral blood mononuclear cell , borrelia burgdorferi , peripheral blood , interferon γ , interferon , immunology , interleukin , virology , interferon gamma , peripheral , medicine , microbiology and biotechnology , biology , cytokine , antibody , in vitro , biochemistry
Cytokine networks initiated by means of innate immunity are regarded as a major determinant of host defence in response to acute infection by bacteria including Borrelia burgdorferi . Herein, we demonstrate that interferon ( IFN )‐α, either endogenously produced after exposure of cells to toll‐like receptor‐9‐activating CpG oligonucleotides or provided as recombinant cytokine, weakens activation of the anti‐bacterial interleukin ( IL )‐1/ IL ‐22 axis in human peripheral blood mononuclear cells exposed to viable B. burgdorferi . As IFN ‐α has been related to pathological dissemination of the spirochaete, data suggest an immunoregulatory role of type I IFN in this context that is able to significantly modify cytokine profiles thereby possibly determining early course of B. burgdorferi infection.