Open AccessPotential application of mi RNA s as diagnostic and therapeutic tools in chronic pancreatitis
Author(s) -
Hu LiangHao,
Ji JunTao,
Li ZhaoShen
Publication year - 2015
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.12603
Subject(s) - microrna , disease , pancreatitis , pancreatic cancer , fibrosis , medicine , bioinformatics , cancer , cancer research , biology , gene , genetics
Chronic pancreatitis ( CP ) is a progressive inflammatory disease typified by end‐stage fibrosis. This disease can also increase the risk of pancreatic cancer. The associated diagnosis, pain and other complications further add to the burden of disease management. In recent years, significant progress has been achieved in identifying mi RNA s and their physiological functions, including mRNA repression and protein expression control. Given the extensive effort made on mi RNA research, a close correlation has been discovered between certain types of mi RNA s and disease progression, particularly for tissue fibrosis. Designing mi RNA ‐related tools for disease diagnosis and therapeutic treatments presents a novel and potential research frontier. In the current review, we discuss various mi RNA s closely interacting with CP , as well as the possible development of targeted mi RNA therapies in managing this disease.